Wednesday, April 10, 2013

Manipulating calcium accumulation in blood vessels may provide a new way to treat heart disease

Apr. 9, 2013 ? Hardening of the arteries, or atherosclerosis, is the primary cause of heart disease. It is caused by calcium accumulation in the blood vessels, which leads to arteries becoming narrow and stiff, obstructing blood flow and leading to heart complications. Although many risk factors for atherosclerosis have been identified, the cause is not known and there is currently no way to reverse it once it sets in. In a new study published 9th April in the open access journal PLOS Biology, researchers have characterized the cells responsible for driving this calcium build-up in vessel walls.

The process of calcium accumulation in blood vessels resembles bone formation and involves maintaining a balance between bone-forming cells called osteoblasts and bone-destroying cells called osteoclasts. In the new study, Hyo-Soo Kim and colleagues characterize the origin of a population of vascular calcifying progenitor cells, and the potential of these cells to differentiate into different cell types.

"We show that vascular calcifying progenitor cells in the artery have the potential to become either osteoblasts or osteoclasts," said Dr Kim of Seoul National University. "And a certain chemical can push these cells towards becoming osteoclasts, which leads to the softening of the blood vessels."

The researchers sorted cells from the aortas of mice into two groups. Both groups originated from bone marrow and expressed a cell surface protein, called Sca-1, but only one group expressed another cell surface protein called PDGFR?. They found that the cells which only expressed Sca-1 could become either osteoblasts or osteoclasts, whereas the cells which expressed both Sca-1 and PDGFR? were committed to an osteoblastic lineage.

The team then treated the cells with a protein called PPAR?, which is known to promote the formation of osteoclasts and inhibit the formation of osteoblasts. When treated with PPAR?, only Sca-1 expressed cells preferentially differentiated into osteoclast-like cells. Furthermore, in vivo study demonstrated that, while bidirectional cells that were injected into mouse models of atherosclerosis increased the severity of calcium build-up in arteries, cells that were then treated with a drug activating PPAR? markedly decreased this effect and even reversed the calcification.

"These findings suggest that a subtype of calcifying progenitor cells offer a new therapeutic target for the prevention of calcification," said Dr Kim. "This opens up the possibility of new drug development to inhibit the hardening of the arteries, and thereby reduce the risk of heart disease."

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The above story is reprinted from materials provided by Public Library of Science.

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Journal Reference:

  1. Hyun-Ju Cho, Hyun-Jai Cho, Ho-Jae Lee, Myung-Kang Song, Ji-Yun Seo, Yeon-Hee Bae, Ju-Young Kim, Hae-Young Lee, Whal Lee, Bon-Kwon Koo, Byung-Hee Oh, Young-Bae Park, Hyo-Soo Kim. Vascular Calcifying Progenitor Cells Possess Bidirectional Differentiation Potentials. PLoS Biology, 2013; 11 (4): e1001534 DOI: 10.1371/journal.pbio.1001534

Note: If no author is given, the source is cited instead.

Disclaimer: This article is not intended to provide medical advice, diagnosis or treatment. Views expressed here do not necessarily reflect those of ScienceDaily or its staff.

Source: http://feeds.sciencedaily.com/~r/sciencedaily/top_news/top_health/~3/xo9b2VM5-30/130409173500.htm

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Tuesday, April 9, 2013

Facebook tweaks Android phones to build new 'Home'

Facebook CEO Mark Zuckerberg speaks at the company's headquarters in Menlo Park, Calif., Thursday, April 4, 2013. Zuckerberg says the company is not building a phone or an operating system. Rather, Facebook is introducing a new experience for Android phones. The idea behind the new Home service is to bring content right to you, rather than require people to check apps on the device. (AP Photo/Marcio Jose Sanchez)

Facebook CEO Mark Zuckerberg speaks at the company's headquarters in Menlo Park, Calif., Thursday, April 4, 2013. Zuckerberg says the company is not building a phone or an operating system. Rather, Facebook is introducing a new experience for Android phones. The idea behind the new Home service is to bring content right to you, rather than require people to check apps on the device. (AP Photo/Marcio Jose Sanchez)

Facebook CEO Mark Zuckerberg walks at the company's headquarters in Menlo Park, Calif., Thursday, April 4, 2013. Zuckerberg says the company is not building a phone or an operating system. Rather, Facebook is introducing a new experience for Android phones. The idea behind the new Home service is to bring content right to you, rather than require people to check apps on the device. (AP Photo/Marcio Jose Sanchez)

Facebook CEO Mark Zuckerberg speaks at the company's headquarters in Menlo Park, Calif., Thursday, April 4, 2013. Zuckerberg says the company is not building a phone or an operating system. Rather, Facebook is introducing a new experience for Android phones. The idea behind the new Home service is to bring content right to you, rather than require people to check apps on the device. (AP Photo/Marcio Jose Sanchez)

Facebook CEO Mark Zuckerberg speaks at the company's headquarters in Menlo Park, Calif., Thursday, April 4, 2013. Zuckerberg says the company is not building a phone or an operating system. Rather, Facebook is introducing a new experience for Android phones. The idea behind the new Home service is to bring content right to you, rather than require people to check apps on the device. (AP Photo/Marcio Jose Sanchez)

Facebook CEO Mark Zuckerberg speaks at the company's headquarters in Menlo Park, Calif., Thursday, April 4, 2013. Zuckerberg says the company is not building a phone or an operating system. Rather, Facebook is introducing a new experience for Android phones. The idea behind the new Home service is to bring content right to you, rather than require people to check apps on the device. (AP Photo/Marcio Jose Sanchez)

MENLO PARK, Calif. (AP) ? With its new "Home" on Android gadgets, Facebook is trying to prove that a company doesn't have to make a smartphone or operating system to define how people interact with mobile technology. The audacious move will provide further insights into how pervasive Facebook has become, testing whether people want to be greeted with content from the social network every time they look at their phones.

When people start downloading the Home software upon its April 12 release in the U.S., Facebook will become the new hub of their Android smartphones.

Switch on your phone and you'll see friends' photos, overlaid by status updates, links and eventually, advertisements in Facebook's quest to bring in more revenue and restore its stock price to where it stood when the company went public nearly 11 months ago.

About 80 percent of what currently appears within a Facebook user's News Feed will automatically be transferred into the "cover feed" of the Home service. For instance, a sibling's status update might be featured prominently on the phone's home screen when it's unlocked. Swipe a finger and there might be a photo posted by one of your best friends. Want to like what you see? Just tap on the home screen twice. Comments can be posted directly from the home screen, too.

If other friends happen to send you a message, their Facebook photo will pop up as a notification.

Other Facebook features, such as video, will be added to Home in future months. A Home version for Android-powered tablet computers also will be coming later this year.

Once they have had their fill of what Facebook is feeding them on the Home service, users can just swipe a finger on the screen to get to all the standard Android apps to listen to music, watch videos or send email.

At first, Home will only work on some Android devices, including HTC Corp.'s One X and One X Plus and Samsung Electronics Co.'s Galaxy S III and Galaxy Note 2. For now, Home isn't compatible with the Nexus phone designed by Google, a fierce Facebook rival whose pliable Android software is being modified to accommodate the new service.

A phone from HTC that comes pre-loaded with Home will be available starting April 12, with AT&T Inc. as the carrier. The HTC First will sell for $99.99 with a two-year data plan from AT&T.

Home is debuting after several years of speculation that Facebook intended to make its own phone or mobile operating system to drive more traffic to its social network. Facebook CEO Mark Zuckerberg said the speculation never made sense to him because he believes a company-produced phone might only end up in the hands of 10 million to 20 million people. The Home service gives Facebook a chance to take control of the main screen of every phone running on Android, the leading mobile operating system. In the U.S. alone, about 64 million people will be relying on Android-driven phones this year, estimated the research firm eMarketer.

"Just building a phone isn't enough for Facebook," Zuckerberg said Thursday during Home's unveiling at the company's Menlo Park, Calif., headquarters.

The idea behind the software is to bring Facebook content right to users' home screens, rather than requiring them to check various apps to see what their friends are up to, or to chat. Down the line, Facebook will integrate its existing camera app and other features. Though cameras and calls won't be built into the initial version of Home, Zuckerberg promised the software will be updated at least once a month to add more features and fix bugs.

"Home" comes amid rapid growth in the number of people who access Facebook from phones and tablet computers. Of the social network's 1.06 billion monthly users, 680 million log in using a mobile gadget. As a result, the money Facebook makes from mobile advertising is also growing. Taking over the entire screen of smartphones and, eventually, tablet computers will provide Facebook for a larger canvas for selling mobile ads.

Zuckerberg, already a multibillionaire, didn't dwell on Home's moneymaking potential Thursday. Instead, he depicted the software as a noble attempt to put a higher priority on personal relationships than utilitarian apps.

"Why do we need to go into all the apps in the first place to see what is going on with the people we care about," he asked.

"We think this is the best version of Facebook there is," he said.

That statement implies that using Facebook on Apple's iPhone and other smartphones may become a less enriching experience. Apple Inc., which rigidly controls how apps work on the operating system built for the iPhone and iPad, has ingrained more Facebook features into the most recent versions of its mobile software.

Apple had no immediate comment about Home.

Zuckerberg said users can have an experience on Android phones unavailable on other platforms because Google makes the software available on an open-source basis. That allows phone manufacturers and software developers to adapt it to their needs.

Recognizing that text messaging is one of the most important tasks on a mobile phone, Facebook programmed Home to include a feature called "chat heads." This lets users communicate with their friends directly from their home screens ? without opening a separate app.

"What Facebook wants is to put itself at the front of the Android user experience for as many Facebook users as possible and make Facebook more elemental to their customers' experience," said Forrester analyst Charles Golvin.

While the Home service probably makes sense for Facebook, Golvin believes the company is overestimating "the extent to which this is something their users want."

"I'm sure there are people out there whose lives revolve around their social network and for them it makes sense to have it front and center," Golvin said. "But this doesn't describe the majority of consumers."

Google Inc. is among the companies hoping that Golvin is correct. The Internet search leader gives away its Android software for free, in the hope that it will steer phone users to ads sold by Google. With Home, Facebook will be muscling its way in between Android users and Google, creating an opportunity for Facebook to seize the advertising advantage.

This is not the first time a big Internet company has co-opted Android: Amazon.com's Kindle Fire tablets run a version of Android that strips out all Google services, replacing them with Amazon's equivalents. Google responded by releasing its own tablet to compete against the Kindle Fire last year.

The mobile advertising market is growing quickly, thanks in large part to Facebook and Twitter, which also entered the space in 2012. EMarketer expects U.S. mobile ad spending to grow 77 percent this year to $7.29 billion, from $4.11 billion last year.

Facebook, meanwhile, is expected to reel in $1.53 billion in worldwide mobile ad revenue this year according to eMarketer, up from $470.7 million last year.

Facebook's stock rose 82 cents, or 3.1 percent, to close Thursday at $27.07. That's 29 percent below its initial public offering price of $38. Meanwhile, the Standard & Poor's 500 index has surged by 20 percent since Facebook's rocky debut.

___

Barbara Ortutay reported from New York. AP Technology Writer Peter Svensson contributed to this story from New York.

Associated Press

Source: http://hosted2.ap.org/APDEFAULT/495d344a0d10421e9baa8ee77029cfbd/Article_2013-04-05-US-TEC-Facebook-Mobile/id-f78b8723e9b746c5ab51eba38c6333c3

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A Woman Robbed a Bank with a Can of Spaghetti Sauce

Of all the food related items or household goods that you could use to pretend to be a bomb, spaghetti sauce has to be pretty low on the list. Not to a 60-year-old woman near Detroit though, she used spaghetti sauce to rob an entire bank. And she got away. More »


Source: http://feeds.gawker.com/~r/gizmodo/full/~3/6DCBXMErmpM/a-woman-robbed-a-bank-with-a-can-of-spaghetti-sauce

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Monday, April 8, 2013

North Korea laborers do not report for work at Kaesong: report

With all this talk about the cord-cutting masses no longer wanting to subsidize TV channels they don't watch, it's a little surprising that one of the oldest, most widely available forms of TV is waning: over-the-air broadcast TV. Despite its attractive price of $0 per month and billions of advertising revenue, nobody ? including the broadcast networks, the tech companies that are out to disrupt them, and the cord-cutters and cord-nevers who hate cable ? is very enthusiastic about antennas. ...

Source: http://news.yahoo.com/north-korea-laborers-not-report-kaesong-report-232336118.html

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Letter: Here's a solution to gang problem | Amarillo Globe-News

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Source: http://amarillo.com/opinion/letters-editor/2013-04-07/letter-heres-solution-gang-problem

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Sunday, April 7, 2013

Kerry heads back to Mideast for fresh peace push

WASHINGTON (AP) ? Secretary of State John Kerry headed to the Middle East on Saturday, his third trip to the region in two weeks, in a fresh bid to unlock long-stalled Israeli-Palestinian peace talks.

Istanbul was the first leg of a six-nation trip that will see him travel on to Europe and Asia.

From Turkey, he planned to go to Jerusalem for meetings with the presidents and prime ministers of both Israel and the Palestinians. Kerry accompanied President Barack Obama there last month and made a solo trip to Israel shortly after.

Though expectations are low for any breakthrough on Kerry's trip, his diplomacy represents some of the Obama administration's most sustained efforts for ending more than six decades of conflict between Israelis and Palestinians.

Kerry probably will seek confidence-building measures between the two sides. Negotiators and observers see little chance right now for immediate progress on the big stumbling blocks toward a two-state peace agreement.

He may have more success on his first stop persuading Turkish leaders to continue improving ties with Israel. The two countries were once allies, but relations spiraled downward after Israel's 2010 raid on a Turkish flotilla bound for the Gaza Strip. Eight Turks and one Turkish-American died.

Hopes for rapprochement improved after Obama brokered a telephone conversation between Israeli Prime Minister Benjamin Netanyahu and Turkey's prime minister, Recep Tayyip Erdogan, while Obama was in Israel.

In Turkey, Kerry also will coordinate with Erdogan and other Turkish officials on efforts to halt the violence in neighboring Syria.

Kerry will also visit Britain and then South Korea, China and Japan, where talks will focus on North Korea's nuclear program and escalating threats against the U.S. and its allies.

He is scheduled to return to Washington on April 15.

Source: http://news.yahoo.com/kerry-heads-back-mideast-fresh-peace-push-083435451--politics.html

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5 Common Myths Exposed About For Sale By Owner Transactions ...

Author: Melissa Gifford | Total views: 198 Comments: 0
Word Count: 734 Date:

A For Sale by Owner type of real estate transaction has several common misconceptions. If you are looking for a place that talks about the myths and facts associated with this type of house sale, you have come to the right place. We are going to address some of the more common misconceptions and misinformation about this type of transaction and show that it can be a positive experience for all parties involved.

Myth #1: I have to know a lot about real estate in order to sell my house on my own. I should be licensed as a real estate agent or at least take some classes.

Truth: While it can be extremely helpful to know the laws about real estate in your area, you do not have to know it all. Many times you can hire an experience real estate lawyer for much less than the agent's commission and you are legally covered. These lawyers can provide you with the necessary contracts so that the sale is legal and binding. You may benefit from real estate classes or some simple online training but you don't have to be licensed to sell your own property. Legally, any owner can sell their property without having a real estate license.

Myth #2: I need to be great with people to sell my house.

Truth: You shouldn't be scared of people. There are some people who have a natural aversion to people and would consider themselves a hermit. Most people, however, can talk to other human beings on a one-on-one basis. If you are nervous in crowds, you have the ability to limit showings to one person at a time. You never have to host an open house and you can ask to only speak with the actual buyer, not their entire family. If you work and interact with people on a daily basis, limited or not, you can perform the necessary talking that will sell your house.

Myth #3: I'll make a larger profit when I do a FSBO.

Truth: While many sellers do report making a larger profit, many experience the benefit of simply not paying money out of their own pocket. In this current housing market, the competition is plentiful and you may need to lower the asking price to compete in the market. You have to be willing to compromise to have a successful sale. When you lower the price, you may not have the leftover money from the sale to pay an agent and concessions. A FSBO will let you skip that part and lower the price enough to sell but you may not make a substantial gain on the house.

Myth #4: People will call and stop by at all hours of the day and night.

Truth: You will get phone calls, emails, and even drive-bys. Don't think of them as a nuisance, but rather as money in your pocket. These are potential buyers and the faster you can get them to buy, the sooner you can be done with the hassles. It may be a pain to have the showings and distribute the info, but in reality when you use an agent, they don't clean for you, make the decisions for you, or even create a budget for you. Those are all items you will do on your own so why pay an agent to do that.

Myth #5: It will hurt my neighbors and area to have a FSBO instead of a "real" sale.

Fact: When a house sells, the price is recorded. Depending on where you live it can be public information. Regardless of how it sells, the information is recorded. Even if you sell your own house, your area will not be hurt by it. Would your neighborhood benefit from a new person moving in and buying the house or from the house sitting vacant with the ability for squatters and vandalism? You need to sell your house so why not do it while you are in control?

Taking control of your real estate situation means doing what is best for you and your situation. Don't allow others to determine or intimidate you into a decision. Real estate gives you the ability to control the future and you can be in complete control of the transaction.

You can find more information on selling your house by visiting www.fastestwaytosellyourhome.com. Let us help provide you with the knowledge you need to sell your house fast without all of the nonsense and hassle!

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1: Jewish Baby Names And Their Meanings ? A Passion For Magnificence

The title of this article, ?Jewish Baby Names and Their Meanings ? A Passion for Magnificence? was inspired by King Solomon He led Israel to brilliance and had a passion for magnificence

2: Gifts vs. Cash -- Wedding Etiquette Q&A

Q: My daughter is getting married in October 2008. Her and her fiance have everything they need for their home. Is it okay to ask for money instead of a gift? If it is okay, how do we word this? st

3: Best Ways To Find People Free Online

With about 50% of the world population able to access the internet, there is now a much better chance to find someone free online This is especially true if the person you are trying to locate lives in a country where internet usage is high

4: How to Grow Organic Vegetables Anywhere in Giant GrowSacks

Original tips for growing any plant organically on the worst possible soil using giant GrowSacks. This clever 'container planting' plan also improves bad soil without extra work or soil amendments.

5: How To Buy High Quality Furniture At Estate Sales

Estate sales and auctions are an excellent place to pick up gently used or even antique furniture at prices considerably less than retail. While it might take patience, it is possible to find reasonable prices on excellent pieces that will last for generations -- saving you money in the long run.

Source: http://www.content4reprint.com/family/5-common-myths-exposed-about-for-sale-by-owner-transactions.htm

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